Common Pain Medication Fuels Cancer Growth

Painkillers known as opiates are widely used to treat both acute and chronic pain. Morphine, in particular, is often used to relieve the pain experienced by cancer patients. But now comes evidence from two new studies that strongly indicates opiate-based painkillers actually fuel the growth and spread of malignancies.

The research presented in Boston on November 18, 2009, at "Molecular Targets and Cancer Therapeutics," a joint meeting of the American Association for Cancer Research, the National Cancer Institute, and the European Organization for Research and Treatment of Cancer, advances the concept that opiate drugs are cancer promoters. The research also explains how protecting cancer cells from opiates may reduce cell proliferation, invasion and migration.

The concept that opiate drugs used to help cancer patients might be contributing to cancer recurrence developed about eight years ago from several unrelated clinical and laboratory studies. First, a 2002 palliative care study found patients who received spinal rather than systemic pain relief from opiate drugs lived longer. A short time later, Jonathan Moss, professor of anesthesiology and critical care at the University of Chicago, reported that several cancer patients receiving a selective opiate blocker called methylnaltrexone (MNTX) which was developed in the 1980s to treat opiate-induced constipation lived far longer than they were expected to. Other studies had similar results.

"These were patients with advanced cancer and a life expectancy of one to two months yet several lived for another five or six. It made us wonder whether this was just a consequence of better GI function or could there possibly be an effect on the tumors," Moss said in a press statement.

Patrick A. Singleton, PhD, assistant professor of medicine at the University of Chicago Medical Center, along with Moss, Joe G.N. Garcia, MD, professor of medicine at the University of Chicago, and colleagues decided to investigate the many peripheral effects of opiates that might encourage cancer growth and the potential benefits of blocking those effects. In laboratory studies using both cell cultures and mice, the scientists found that morphine did directly rev up the proliferation of tumor cells. It also inhibited the immune response, and promoted angiogenesis (the growth of the blood vessels that help "feed" tumors and allow them to thrive). In the research just presented by Singleton and colleagues, they focused on the mu opiate receptor as a regulator of tumor growth and metastasis and they documented the ability of MNTX to block the cancer-promoting effects of opiates on this receptor.

Bottom line: it appears time for doctors and patients to consider all the side effects of opiate pain relievers, including the fact they may spur cancer to grow. Blocking the cancer-fueling ability of opiates and/or using them for as short a time as possible -- or not at all unless absolutely necessary -- appears to be the safest, and healthiest course of action.

Source:  NaturalNews

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The new program, which now must be approved by Congress, much extends aid to Georgia, which in recent years has taken a clear pro-American position, which helped maximize the deterioration of US relations with Russia since the Cold War. Compared to the current through last years infusion seem minimal: while the US has provided 63 million dollars. Approximately one third of this sum went to the education of soldiers, police officers and border guards. so long not counting Iraq, the new investments will make Georgia one of the largest recipients of American aid (after Israel and Egypt). for 17 years have passed since receipt of independence after the collapse of the Soviet Union, the United States has provided her with about 1.8 billion dollars. Secretary of State Condoleezza Rice, speaking in Washington, said that this years aid amount to $ 570 million, while the fate of the remaining money rather obey the terms of the solutions the next administration prezidenthotya the new Congress. 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President Dmitry Medvedev and Prime Minister Vladimir Putin have said that humanitarian supplies by the American Navy and Air Force, are fronts for the supply of new weapons. U.S. administration officials have called the accusations groundless. At the present time the U.S. military brought into the country in an emergency $ 30 million. for those goods were 1,2 thousand tons of food and items for the refugees (eg, tents) - in their delivery of 61 aircraft were involved in the Air Force and two Navy ship, heading to the Black Sea. shutting down, Bush instructed federal agencies to expand opportunities for US trade with Georgia and to provide maritime insurance ships arriving in Georgia. The free world can not afford to let the fate of small independent State to determine the aggression of a larger neighbor, - Rice said in Washington. They took the opportunity to deride the Russian recognition of South Ossetia and another breakaway region of Georgia over the republic - Abkhazia. The secretary said that the Russian example was followed by a few countries. Not too impressive list: Abkhazia and South Ossetia recognize each other - she said. Earlier this week, the European Union has promised to accept the patronage of funding the restoration of Georgia, and the International Monetary Fund agreed to give the country $ 750 million. All these steps have demonstrated broad support, which is received in the international arena, the power of Georgia and its leader, Mikhail Saakashvili - the same one whom Medvedev this week called a political corpse. During that time , but it seems that some SShno European countries there is no way to stately pressure to Russia to convince her to stop the confrontation with the government of Saakashvili. Many in the U.S. administration fears that Russia is determined to overthrow the government of Saakashvili. Even though the authorities clearly demonstrated Georgias political, diplomatic and economic support, Washington has only to decide what steps to take to punish Russia - if such steps will follow along. At first measures were taken, although American and European officials quickly condemned Russia for violating the terms signed by about French-brokered truce agreement. This document requires a stop fighting and withdraw Russian troops from Georgian territory. According to officials, will soon announce the government for a waiver through an agreement according to Russian cooperation in the field of peaceful nuclear technology - a key point of Bushs consistent anti-nuclear proliferation. during that time but little with the source noted that the final verdict is still pending. If only Congress and before the connection is perceived with skepticism, cancellation of an international agreement that Bush and Putin have called a major achievement, and quite pretty significant step. Georgia has already convinced America to take urgent steps to restore its armed forces. Officials acknowledge that reflect on the proposal, but at the same time make it clear that fear add fuel to the fire of conflict, which is far above a permit. Only expected an extended plan consistent with humanitarian and economic assistance will not meet serious opposition in Congress. Senator Joseph R. Biden Jr., The head of the Commission according to Foreign Affairs and wait for the vice-presidency by the Democratic Party, has expressed support for such a great help. Throughout the environment in Azerbaijan, Cheney spoke directly against the Russian words on the favorites Georgian leader. A trip to Azerbaijan - a little bit with the three steps the vice-president in an attempt to strengthen the faith of the countries bordering on Russia in the face of newly recruited determination and much larger neighbor. Dick Cheney - now with a senior U.S. official with the number of visiting Azerbaijan since in 1991 it proclaimed independence. during the day, Cheney plans to visit Georgia, and then in Ukraine. We met this evening in the light of the recent Russian invasion of Georgia, a step that the international community to freely denounced - Cheney said during talks with Azeri President Ilham Aliyev was held at the residence Zagulba Baglary in the Caspian Sea coast. President Bush has sent me here with a clear and simple message to the people Azerbaydzhanhotya throughout the region: The United States has deep and lasting interest in your welfare and safety. Azerbaijan, like Georgia , first was a mixture of the USSR, and now aims for closer ties with the West and the US. party is a vital crossroads in the supply of oil and gazhotya is the Caspian Sea and other regions of Central Asia. This has been underlined by the fact that the first meetings in Baku, Cheney held with representatives of two international oil companies: William Schrader of BP Azerbaijan and Robert Branch Destmalchi with Chevron, as reported by his secretary Megan Mitchell presvmeste. for the day before these meetings, Putin announced plans for a consistent construction of a new gazoprovodhotya is Central Asia to Russia - a route that will increase employment in the Russian natural gas supplies to Europe. Cheney, who in 2006 accused Russia of using its natural resources as tools of intimidation or blackmail, named after the US administration has expressed strong support for efforts to meet the alternative routes for supplies of oil and gazhotya is Central Asia and the Caspian Sea. The United States is deeply convinced that together with the European countries, including Turkey, I need help with Azerbaijan and other countries Kavkazhotya Central Asia to create additional energy export routes, which will provide a lot of free resources - he said. - Energy security is very important for us all, and this issue becomes quite more urgent. Steven Lee MyersSimilar records:

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